TMSB15B

Chr X

thymosin beta 15B

Also known as: TMSL8, Tbeta15b

NCBI Gene: 286527 ENSG00000158427 UniProt: P0CG35 OMIM: 301011

The protein binds and sequesters actin monomers to regulate cytoskeleton organization and inhibit actin polymerization, and is involved in cell migration. Currently, no human diseases have been definitively associated with TMSB15B mutations in the medical literature. The gene shows moderate tolerance to loss-of-function variants based on population genetics data.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable actin monomer binding activity and protein sequestering activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be part of filamentous actin. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.73

LOEUF

GOF

Mechanism· predicted