TMSB15A

Chr X

thymosin beta 15A

Also known as: TMSB15, TMSL8, TMSNB, Tb15, TbNB

NCBI Gene: 11013 ENSG00000158164 UniProt: P0CG34

The protein binds to and sequesters actin monomers, inhibiting actin polymerization and playing an important role in cytoskeletal organization. Currently, no definitive human disease associations have been established for mutations in this gene. The gene shows moderate tolerance to loss-of-function variation with a pLI of 0.39 and LOEUF of 1.73.

ResearchSummary from RefSeq, UniProt

Predicted to enable actin monomer binding activity and protein sequestering activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be part of filamentous actin. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.73

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

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