TMPRSS7
Chr 3transmembrane serine protease 7
Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position
ResearchGenerating clinical summary…
Some data sources returned errors (1)
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.10LOEUF
pLI 0.000
Z-score 1.07
OE 0.81 (0.61–1.10)
Highly tolerant — LoF variants common in population
Missense Constraint?
0.40Z-score
OE missense 0.94 (0.86–1.03)
370 obs / 392.4 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.81 (0.61–1.10)
0≤0.351.4
Missense OE?0.94 (0.86–1.03)
0≤0.61.4
Synonymous OE?1.02
0≤1.21.6
LoF obs/exp: 31 / 38.1Missense obs/exp: 370 / 392.4Syn Z: -0.21
ClinVar
No ClinVar data available.
Protein Context — Lollipop Plot
TMPRSS7 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools