TMPRSS2
Chr 21transmembrane serine protease 2
Also known as: PRSS10
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TMPRSS2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Comparative Study of Radiotherapy Treatments to Treat High Risk Prostate Cancer Patients
ACTIVE NOT RECRUITINGProBio: A Biomarker Driven Study in Patients With Metastatic Prostate Cancer
RECRUITINGComparing the Reliability of Expressed Prostatic Secretion (EPS) and Post Massage Urine (PMU) for the Prediction of Prostate Cancer Biopsy Outcome
ACTIVE NOT RECRUITINGA Study of Apabetalone in Subjects With Long -COVID
RECRUITINGProsTIC Registry of Men Treated With PSMA Theranostics
ACTIVE NOT RECRUITINGThe Predictive Value of Coexisting TMPRSS2-ERG Gene Fusion and PTEN Deletion in Prostate Cancer Patients with Biochemical Failure Status Post Salvage or Radical Radiation Therapy
RECRUITINGMolecular Mechanisms of Dutasteride and Dietary Interventions to Prevent Prostate Cancer and Reduce Its Progression
ACTIVE NOT RECRUITINGIn Men With Metastatic Prostate Cancer, What is the Safety and Benefit of Lutetium-177 PSMA Radionuclide Treatment in Addition to Chemotherapy
ACTIVE NOT RECRUITINGEDRN Prostate MRI Biomarker Study
RECRUITINGCirculating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy
RECRUITINGThe Role of Obesity in Severe COVID-19 Pathophysiology
RECRUITINGExternal Resources
Links to major genomics databases and tools