TMOD4

Chr 1

tropomodulin 4

Also known as: SK-TMOD

NCBI Gene: 29765ENSG00000163157UniProt: Q9NZQ9

Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Located in striated muscle thin filament. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
4
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.09
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.09LOEUF
pLI 0.000
Z-score 1.25
OE 0.71 (0.47–1.09)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.71Z-score
OE missense 0.86 (0.76–0.97)
177 obs / 205.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.71 (0.47–1.09)
0≤0.351.4
Missense OE?0.86 (0.76–0.97)
0≤0.61.4
Synonymous OE?0.84
0≤1.21.6
LoF obs/exp: 15 / 21.2Missense obs/exp: 177 / 205.8Syn Z: 1.05

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TMOD4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients