TMEM95
Chr 17transmembrane protein 95
Also known as: UNQ9390
The protein is required for fusion of sperm with the egg membrane during fertilization. Mutations in this gene cause male infertility due to defective sperm-egg membrane fusion. The gene shows very low constraint against loss-of-function variants, consistent with its specific role in male fertility rather than essential cellular functions.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TMEM95 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools