TMEM8B
Chr 9transmembrane protein 8B
Also known as: C9orf127, FP588, LINC00950, NAG-5, NAG5, NGX6, NGX6a
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.95LOEUF
pLI 0.000
Z-score 1.73
OE 0.59 (0.38–0.95)
Typical tolerance to LoF variation
Missense Constraint?
1.91Z-score
OE missense 0.69 (0.62–0.78)
210 obs / 303.5 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.59 (0.38–0.95)
0≤0.351.4
Missense OE?0.69 (0.62–0.78)
0≤0.61.4
Synonymous OE?0.99
0≤1.21.6
LoF obs/exp: 12 / 20.5Missense obs/exp: 210 / 303.5Syn Z: 0.11
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TMEM8B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools