TMEM275

Chr 1

transmembrane protein 275

NCBI Gene: 105378696ENSG00000282881UniProt: A0A0U1RQS6

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

2
ClinVar variants
1
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TMEM275
📋
ClinVar Variants
1 Pathogenic / Likely Pathogenic of 2 total submissions
Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

2 submitted variants in ClinVar

ClinVar

Classification Summary

Likely Pathogenic1
Likely Benign1
1
Likely Pathogenic
1
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
0
0
0
Likely Pathogenic
0
0
1
0
1
VUS
0
0
0
0
0
Likely Benign
0
1
0
0
1
Benign
0
0
0
0
0
Total01102

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TMEM275 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for TMEM275

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools