TMEM273

Chr 10

transmembrane protein 273

Also known as: C10orf128

NCBI Gene: 170371ENSG00000204161UniProt: Q5T292

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.44
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.44LOEUF
pLI 0.006
Z-score 0.84
OE 0.64 (0.31–1.44)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.64Z-score
OE missense 1.23 (1.02–1.49)
74 obs / 60.1 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.64 (0.31–1.44)
0≤0.351.4
Missense OE?1.23 (1.02–1.49)
0≤0.61.4
Synonymous OE?1.09
0≤1.21.6
LoF obs/exp: 4 / 6.3Missense obs/exp: 74 / 60.1Syn Z: -0.34

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TMEM273 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients