TMEM266

Chr 15

transmembrane protein 266

Also known as: C15orf27, HVRP1, HsHVRP1, hTMEM266

NCBI Gene: 123591 ENSG00000169758 UniProt: Q2M3C6

Enables protein homodimerization activity. Predicted to be involved in monoatomic ion transport and transmembrane transport. Located in cytosol; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.98

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

0.98LOEUF

pLI 0.000

Z-score 1.63

OE 0.63 (0.41–0.98)

Tolerant

Typical tolerance to LoF variation

Missense Constraint?

0.75Z-score

OE missense 0.88 (0.80–0.97)

278 obs / 315.5 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.63 (0.41–0.98)

0≤0.351.4

Missense OE?0.88 (0.80–0.97)

0≤0.61.4

Synonymous OE?1.09

0≤1.21.6

LoF obs/exp: 14 / 22.3Missense obs/exp: 278 / 315.5Syn Z: -0.82

Background carrier burden — how many people carry a rare variant somewhere in TMEM266?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 71

710 rare PASS variants

Rare truncating (LoF)

1 in 2,000

99 rare PASS variants

Rare synonymous (reference)

1 in 120

334 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for TMEM266. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 140	1 in 2,000
South Asian	~43k	1 in 84	1 in 1,600
Remaining (unassigned)	~30k	1 in 68	1 in 1,900
European (Finnish)	~27k	1 in 500	≈ 1 in 24,000
Admixed American	~22k	1 in 55	1 in 1,400
African / African American	~21k	1 in 58	1 in 1,300
East Asian	~20k	1 in 87	1 in 1,000
Ashkenazi Jewish	~13k	1 in 360	≈ 1 in 6,500
Middle Eastern	~2,884	1 in 93	≈ 1 in 2,900

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 9 of 10 coding exons well covered in gnomAD exomes; exon 9 marginal. Genomes: all 10.? see exons ↓