TMEM235
Chr 17transmembrane protein 235
Also known as: ARGM1
Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Clinical Summary— TMEM235
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Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
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ClinVar Variants
14 Pathogenic / Likely Pathogenic· 42 VUS of 60 total submissions
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
1.39LOEUF
pLI 0.000
Z-score 0.79
OE 0.71 (0.39–1.39)
Highly tolerant — LoF variants common in population
Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
0.49Z-score
OE missense 0.87 (0.73–1.03)
94 obs / 108.4 exp
Mild missense constraint
Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.71 (0.39–1.39)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.87 (0.73–1.03)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.94
0≤1.21.6
LoF obs/exp: 6 / 8.5Missense obs/exp: 94 / 108.4Syn Z: 0.37
ClinVar Variant Classifications
60 submitted variants in ClinVar
Classification Summary
Pathogenic13
Likely Pathogenic1
VUS42
Likely Benign4
13
Pathogenic
1
Likely Pathogenic
42
VUS
4
Likely Benign
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 13 | 0 | 13 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 0 | 41 | 1 | 0 | 42 |
Likely Benign | 0 | 3 | 1 | 0 | 4 |
Benign | 0 | 0 | 0 | 0 | 0 |
| Total | 0 | 44 | 16 | 0 | 60 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
TMEM235 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype Relationships
1 OMIM entry
TRANSMEMBRANE PROTEIN 235; TMEM235
MIM #620272 · *
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Lnc Tmem235 promotes repair of early steroid-induced osteonecrosis of the femoral head by inhibiting hypoxia-induced apoptosis of BMSCs.
Zhang F et al.·Exp Mol Med
2022Open Access
Top 5 resultsSearch Europe PMC ↗
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Characterization of the Expressions and m6A Methylation Modification Patterns of mRNAs and lncRNAs in a Spinal Cord Injury Rat Model
Liu X et al.·Mol Neurobiol
2024Functional
Transcriptomics and Spatial Proteomics for Discovery and Validation of Missing Proteins in the Human Ovary
Méar L et al.·J Proteome Res
2024
Protein-protein interaction network analysis applied to DNA copy number profiling suggests new perspectives on the aetiology of Mayer-Rokitansky-Kuster-Hauser syndrome
Pontecorvi P et al.·Sci Rep
2021
Emerging perspectives on osteonecrosis of the femoral head: the role of circular RNAs and long non-coding RNAs - a systematic review
Lin F et al.·Front Genet
2025Review
SOCS3 Acts as an Onco-immunological Biomarker With Value in Assessing the Tumor Microenvironment, Pathological Staging, Histological Subtypes, Therapeutic Effect, and Prognoses of Several Types of Cancer
Dai L et al.·Front Oncol
2022
Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells
Huang C et al.·Biomolecules
2023Functional
Construction and analysis for dys-regulated lncRNAs and mRNAs in LPS-induced porcine PBMCs
Zhang J et al.·Innate Immun
2021
Top 8 full-text resultsSearch PubTator3 ↗
External Resources
Links to major genomics databases and tools