TMEM225B

Chr 7

transmembrane protein 225B

Also known as: GS1-259H13.2

NCBI Gene: 100289187ENSG00000244219UniProt: P0DP42

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

8
ClinVar variants
6
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TMEM225B
📋
ClinVar Variants
6 Pathogenic / Likely Pathogenic· 1 VUS of 8 total submissions
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

8 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic6
VUS1
Likely Benign1
6
Pathogenic
1
VUS
1
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
6
0
6
Likely Pathogenic
0
0
0
0
0
VUS
0
1
0
0
1
Likely Benign
0
0
1
0
1
Benign
0
0
0
0
0
Total01708

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TMEM225B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found

Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools