TMEM225

Chr 11

transmembrane protein 225

Also known as: PMP22CD, PPP1R154, SPATA47

NCBI Gene: 338661 ENSG00000204300 UniProt: Q6GV28

TMEM225 encodes a protein that inhibits protein phosphatase 1 (PP1) in sperm by binding to the catalytic subunit PPP1CC and is located in acrosomal membranes. Based on the available data, no specific diseases have been definitively associated with mutations in this gene. The gene shows low constraint against loss-of-function variants (pLI 0.002, LOEUF 1.42), suggesting tolerance to such mutations.

ResearchSummary from RefSeq, UniProt

Predicted to enable protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in inner acrosomal membrane and outer acrosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.42

LOEUF

Multiple*

Mechanism· predicted