TMEM215

Chr 9

transmembrane protein 215

NCBI Gene: 401498ENSG00000188133UniProt: Q68D42

Acts upstream of or within negative regulation of endothelial cell apoptotic process; negative regulation of programmed necrotic cell death; and sprouting angiogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.58
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.58LOEUF
pLI 0.004
Z-score 0.62
OE 0.72 (0.35–1.58)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.82Z-score
OE missense 0.81 (0.69–0.94)
113 obs / 140.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.72 (0.35–1.58)
0≤0.351.4
Missense OE?0.81 (0.69–0.94)
0≤0.61.4
Synonymous OE?0.82
0≤1.21.6
LoF obs/exp: 4 / 5.6Missense obs/exp: 113 / 140.3Syn Z: 1.11

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TMEM215 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients