TMEM191C

Chr 22

transmembrane protein 191C

NCBI Gene: 645426ENSG00000206140UniProt: A6NGB0

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

107
ClinVar variants
86
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TMEM191C
📋
ClinVar Variants
86 Pathogenic / Likely Pathogenic· 17 VUS of 107 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

107 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic84
Likely Pathogenic2
VUS17
Benign1
84
Pathogenic
2
Likely Pathogenic
17
VUS
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————84
Likely Pathogenic
————2
VUS
————17
Likely Benign
————0
Benign
————1
Total—104

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TMEM191C · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for TMEM191C

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools