TMEM170B
Chr 6transmembrane protein 170B
Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
Clinical highlights
Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?
0.58LOEUF
pLI 0.787
Z-score 2.10
OE 0.00 (0.00–0.58)
More LoF-intolerant than ~75% of genes
Missense Constraint?
1.24Z-score
OE missense 0.57 (0.43–0.75)
37 obs / 65.2 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.00 (0.00–0.58)
0≤0.351.4
Missense OE?0.57 (0.43–0.75)
0≤0.61.4
Synonymous OE?0.79
0≤1.21.6
LoF obs/exp: 0 / 5.1Missense obs/exp: 37 / 65.2Syn Z: 0.87
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TMEM170B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools