TMEM156

Chr 4

transmembrane protein 156

NCBI Gene: 80008ENSG00000121895UniProt: Q8N614

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.66
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.66LOEUF
pLI 0.000
Z-score -0.25
OE 1.08 (0.71–1.66)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.19Z-score
OE missense 1.04 (0.92–1.19)
157 obs / 150.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.08 (0.71–1.66)
0≤0.351.4
Missense OE?1.04 (0.92–1.19)
0≤0.61.4
Synonymous OE?1.04
0≤1.21.6
LoF obs/exp: 14 / 13.0Missense obs/exp: 157 / 150.3Syn Z: -0.25

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TMEM156 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients