TMEM154

Chr 4

transmembrane protein 154

NCBI Gene: 201799ENSG00000170006UniProt: Q6P9G4

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
8
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.61
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.61LOEUF
pLI 0.000
Z-score 0.10
OE 0.97 (0.59–1.61)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.88Z-score
OE missense 1.25 (1.08–1.46)
119 obs / 94.9 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.97 (0.59–1.61)
0≤0.351.4
Missense OE?1.25 (1.08–1.46)
0≤0.61.4
Synonymous OE?0.83
0≤1.21.6
LoF obs/exp: 10 / 10.3Missense obs/exp: 119 / 94.9Syn Z: 0.78

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TMEM154 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients