TIGIT
Chr 3T cell immunoreceptor with Ig and ITIM domains
Also known as: VSIG9, VSTM3, WUCAM
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TIGIT · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
GPC3-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression
RECRUITINGRare Tumor Focused Platform Study of Innovative Therapies and Technologies (PLATFORM2)
NOT YET RECRUITINGCombination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas
RECRUITINGNK521 in the Treatment of Advanced Solid Tumors
NOT YET RECRUITINGNK521 in the Treatment of Malignant Ascites Associated With Advanced Solid Tumors
RECRUITINGTiragolumab and Atezolizumab in Advanced Pan-cancer Patients
RECRUITINGExternal Resources
Links to major genomics databases and tools