THYN1

Chr 11

thymocyte nuclear protein 1

Also known as: HSPC144, MDS012, MY105, THY28, THY28KD

This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

OMIMResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.92
LOEUF
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.92LOEUF
pLI 0.000
Z-score -1.75
OE 1.52 (1.051.92)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.19Z-score
OE missense 0.95 (0.821.11)
120 obs / 125.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.52 (1.051.92)
00.351.4
Missense OE?0.95 (0.821.11)
00.61.4
Synonymous OE?1.22
01.21.6
LoF obs/exp: 20 / 13.1Missense obs/exp: 120 / 125.8Syn Z: -1.10

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

THYN1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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