TEX26

Chr 13

testis expressed 26

Also known as: C13orf26

NCBI Gene: 122046 ENSG00000175664 UniProt: Q8N6G2

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Research

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.40

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.40LOEUF

pLI 0.000

Z-score 0.38

OE 0.90 (0.59–1.40)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

-1.14Z-score

OE missense 1.26 (1.12–1.43)

184 obs / 145.5 exp

Tolerant

Tolerant to missense variation

Observed / Expected Ratios?

LoF OE?0.90 (0.59–1.40)

0≤0.351.4

Missense OE?1.26 (1.12–1.43)

0≤0.61.4

Synonymous OE?1.25

0≤1.21.6

LoF obs/exp: 14 / 15.6Missense obs/exp: 184 / 145.5Syn Z: -1.41

Background carrier burden — how many people carry a rare variant somewhere in TEX26?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 150

395 rare PASS variants

Rare truncating (LoF)

1 in 1,200

72 rare PASS variants

Rare synonymous (reference)

1 in 680

142 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for TEX26. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 270	1 in 1,600
South Asian	~43k	1 in 110	1 in 590
Remaining (unassigned)	~30k	1 in 100	1 in 450
European (Finnish)	~27k	1 in 740	≈ 1 in 8,900
Admixed American	~22k	1 in 110	1 in 1,400
African / African American	~21k	1 in 140	1 in 430
East Asian	~20k	1 in 82	1 in 280
Ashkenazi Jewish	~13k	1 in 2,600	≈ 1 in 13,000
Middle Eastern	~2,884	1 in 90	≈ 1 in 1,400

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 6 of 7 coding exons well covered in gnomAD exomes; exon 7 marginal. Genomes: all 7.? see exons ↓