TDRD10
Chr 1tudor domain containing 10
Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be active in membrane and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.92LOEUF
pLI 0.000
Z-score 1.83
OE 0.56 (0.35–0.92)
Typical tolerance to LoF variation
Missense Constraint?
1.01Z-score
OE missense 0.81 (0.71–0.91)
171 obs / 212.3 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.56 (0.35–0.92)
0≤0.351.4
Missense OE?0.81 (0.71–0.91)
0≤0.61.4
Synonymous OE?0.96
0≤1.21.6
LoF obs/exp: 11 / 19.8Missense obs/exp: 171 / 212.3Syn Z: 0.33
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TDRD10 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools