TCERG1L
Chr 10transcription elongation regulator 1 like
This gene encodes a protein predicted to bind RNA polymerase and function as a transcription coregulator in the nucleus. The gene shows minimal constraint against loss-of-function variants, and no definitive disease associations have been established in humans. Currently, there is insufficient evidence to determine specific disease phenotypes or inheritance patterns associated with TCERG1L mutations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
219 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 92 | 0 | 92 |
Likely Pathogenic | 0 | 0 | 4 | 0 | 4 |
VUS | 0 | 96 | 9 | 0 | 105 |
Likely Benign | 0 | 6 | 3 | 2 | 11 |
Benign | 0 | 0 | 1 | 0 | 1 |
| Total | 0 | 102 | 109 | 2 | 213 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
TCERG1L · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools