TCEANC

Chr X

transcription elongation factor A N-terminal and central domain containing

Also known as: TCEANC1

NCBI Gene: 170082 ENSG00000176896 UniProt: Q8N8B7

This gene encodes a protein predicted to regulate transcription by RNA polymerase II in the nucleus. The gene shows tolerance to loss-of-function variants (pLI = 0.05, LOEUF = 1.07), and no established disease associations have been reported to date.

ResearchSummary from RefSeq

Predicted to enable transcription elongation factor activity. Predicted to be involved in transcription elongation by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.07

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.07LOEUF

pLI 0.052

Z-score 1.46

OE 0.41 (0.19–1.07)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

0.28Z-score

OE missense 0.93 (0.79–1.09)

108 obs / 116.5 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.41 (0.19–1.07)

0≤0.351.4

Missense OE?0.93 (0.79–1.09)

0≤0.61.4

Synonymous OE?0.90

0≤1.21.6

LoF obs/exp: 3 / 7.2Missense obs/exp: 108 / 116.5Syn Z: 0.50

Background carrier burden — how many people carry a rare variant somewhere in TCEANC?

gnomAD v4 · ~732k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 110

294 rare PASS variants

Rare truncating (LoF)

1 in 1,700

42 rare PASS variants

Rare synonymous (reference)

1 in 380

95 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for TCEANC. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~561k	1 in 190	1 in 1,300
South Asian	~36k	1 in 170	1 in 3,600
Remaining (unassigned)	~31k	1 in 140	≈ 1 in 7,500
European (Finnish)	~27k	1 in 880	≈ 1 in 13,000
Admixed American	~23k	1 in 250	1 in 1,100
African / African American	~21k	1 in 200	1 in 1,500
East Asian	~20k	1 in 260	1 in 2,300
Ashkenazi Jewish	~13k	1 in 1,100	none seen
Middle Eastern	~2,758	1 in 340	≈ 1 in 2,700

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.