TCEAL2

Chr X

transcription elongation factor A like 2

Also known as: MY0876G05, WEX1, my048

NCBI Gene: 140597 ENSG00000184905 UniProt: Q9H3H9

The protein functions as a nuclear phosphoprotein that modulates transcription in a promoter context-dependent manner. Mutations in this X-linked gene have not been definitively associated with human disease. The gene shows moderate tolerance to loss-of-function variants based on population genetics data.

ResearchSummary from RefSeq, UniProt

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.81

LOEUF

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Mechanism

Some data sources returned errors (1)

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