TATDN2
Chr 3TatD DNase domain containing 2
TATDN2 encodes a magnesium-dependent RNA nuclease that resolves R-loops (RNA-DNA hybrid structures) to maintain genomic stability in the nucleus. The gene is highly constrained against loss-of-function variants (pLI ~0, LOEUF 0.84), but associated diseases and inheritance patterns have not yet been established in the medical literature.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Tolerant to missense variation
ClinVar Variant Classifications
180 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 41 | 0 | 41 |
Likely Pathogenic | 0 | 0 | 3 | 0 | 3 |
VUS | 0 | 100 | 12 | 0 | 112 |
Likely Benign | 0 | 7 | 0 | 3 | 10 |
Benign | 0 | 0 | 0 | 0 | 0 |
| Total | 0 | 107 | 56 | 3 | 166 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
TATDN2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools