TATDN2

Chr 3

TatD DNase domain containing 2

NCBI Gene: 9797ENSG00000157014UniProt: Q93075OMIM: 619330

Predicted to enable exonuclease activity and metal ion binding activity. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.84
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.84LOEUF
pLI 0.000
Z-score 2.22
OE 0.54 (0.36–0.84)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
-0.05Z-score
OE missense 1.01 (0.93–1.09)
423 obs / 419.9 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.54 (0.36–0.84)
0≤0.351.4
Missense OE?1.01 (0.93–1.09)
0≤0.61.4
Synonymous OE?1.07
0≤1.21.6
LoF obs/exp: 15 / 27.6Missense obs/exp: 423 / 419.9Syn Z: -0.65

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TATDN2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients