TASOR2

Chr 10

transcription activation suppressor family member 2

Also known as: C10orf18, FAM208B, bA318E3.2

NCBI Gene: 54906 ENSG00000108021 UniProt: Q5VWN6 OMIM: 621243

TASOR2 encodes a core scaffolding component of the HUSH2 complex that mediates epigenetic repression of interferon-stimulated genes through recruitment of other complex members. The gene is highly constrained against loss-of-function variants (LOEUF 0.332), suggesting that mutations would likely cause severe developmental consequences. However, no specific genetic disorders have been definitively associated with TASOR2 mutations to date.

OMIM ResearchSummary from RefSeq, UniProt

Enables protein-macromolecule adaptor activity. Involved in negative regulation of gene expression, epigenetic and negative regulation of type I interferon production. Located in cytosol and nucleoplasm. Part of HUSH2 complex. Is active in chromatin and nucleus. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.33

LOEUF· LoF intol.

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Mechanism