TAS2R7

Chr 12

taste 2 receptor member 7

Also known as: T2R7, TRB4

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
P/LP submissions
P/LP missense
1.26
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.26LOEUF
pLI 0.032
Z-score 1.16
OE 0.49 (0.221.26)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.06Z-score
OE missense 1.23 (1.101.39)
200 obs / 162.1 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.49 (0.221.26)
00.351.4
Missense OE?1.23 (1.101.39)
00.61.4
Synonymous OE?1.17
01.21.6
LoF obs/exp: 3 / 6.1Missense obs/exp: 200 / 162.1Syn Z: -1.08

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TAS2R7 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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