TAS1R3

Chr 1

taste 1 receptor member 3

ENSG00000169962 UniProt: Q7RTX0 OMIM: 605865

The protein is a G-protein coupled receptor that forms heterodimeric taste receptors, combining with TAS1R1 to detect umami taste stimuli or with TAS1R2 to recognize sweet compounds including natural and synthetic sweeteners. The gene shows very low constraint against loss-of-function variants, and no clear Mendelian diseases have been established from TAS1R3 mutations based on the available data.

OMIM ResearchSummary from RefSeq, UniProt

Key component of the sweet and umami taste receptors (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). TAS1R1 and TAS1R3 form the umami receptor and respond to the umami taste stimulus (the taste of monosodium glutamate) (PubMed:11917125). TAS1R2 and TAS1R3 form the sweet taste receptor and recognize diverse natural and synthetic sweeteners (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359). Essential for the recognition and response to the disaccharide trehalose (PubMed:12892531). Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity)

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.56

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)