TAL1
Chr 1TAL bHLH transcription factor 1, erythroid differentiation factor
Also known as: SCL, TCL5, bHLHa17, tal-1
TAL1 encodes a transcription factor that regulates hemopoietic differentiation and serves as a positive regulator of erythroid cell development. Somatic mutations in TAL1 are associated with T-cell acute lymphoblastic leukemia, which typically presents in childhood. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.704), consistent with its role in normal hematopoiesis.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TAL1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools