TADA2A
Chr 17transcriptional adaptor 2A
Also known as: ADA2, ADA2A, KL04P, TADA2L, hADA2
The TADA2A protein is a component of the ATAC histone acetyltransferase complex that acetylates histones H3 and H4, binds double-stranded DNA, and plays a role in chromatin remodeling and transcriptional activation. Mutations cause autosomal dominant intellectual disability with developmental delay, and the gene is highly intolerant to loss-of-function variants. This condition primarily affects neurodevelopment and cognitive function.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TADA2A · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools