TAAR9

Chr 6

trace amine associated receptor 9

Also known as: TA3, TAR3, TAR9, TRAR3

NCBI Gene: 134860ENSG00000237110UniProt: Q96RI9

TAAR9 is a member of a large family of rhodopsin G protein-coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Jul 2005]

75
ClinVar variants
11
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TAAR9
📋
ClinVar Variants
11 Pathogenic / Likely Pathogenic· 59 VUS of 75 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

75 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic11
VUS59
Likely Benign5
11
Pathogenic
59
VUS
5
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
11
0
11
Likely Pathogenic
0
0
0
0
0
VUS
0
57
2
0
59
Likely Benign
0
2
0
3
5
Benign
0
0
0
0
0
Total05913375

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TAAR9 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats.
Zhukov IS et al.·Front Pharmacol
2025🔓 Open Access
Structural bioinformatic study of six human olfactory receptors and their AlphaFold3 predicted water-soluble QTY variants and OR1A2 with an odorant octanoate and TAAR9 with spermidine.
Johnsson F et al.·QRB Discov
2025🔓 Open Access
Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats.
Zhukov IS et al.·Biomolecules
2022🔓 Open Access
Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors.
Xu Z et al.·Sci Rep
2022🔓 Open AccessFunctional
Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels.
Murtazina RZ et al.·Int J Mol Sci
2021🔓 Open Access
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools