TAAR6

Chr 6

trace amine associated receptor 6

Also known as: TA4, TAR4, TAR6, TRAR4, taR-4, taR-6

NCBI Gene: 319100ENSG00000146383UniProt: Q96RI8

This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]

ResearchGenerating clinical summary…
0
Active trials
6
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.07
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.07LOEUF
pLI 0.017
Z-score 1.44
OE 0.47 (0.23–1.07)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.15Z-score
OE missense 1.24 (1.11–1.38)
228 obs / 184.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.47 (0.23–1.07)
0≤0.351.4
Missense OE?1.24 (1.11–1.38)
0≤0.61.4
Synonymous OE?1.28
0≤1.21.6
LoF obs/exp: 4 / 8.5Missense obs/exp: 228 / 184.2Syn Z: -1.93

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TAAR6 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients