TAAR5

Chr 6

trace amine associated receptor 5

Also known as: PNR, taR-5

NCBI Gene: 9038ENSG00000135569UniProt: O14804

Enables trimethylamine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
13
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.93
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.93LOEUF
pLI 0.000
Z-score -1.44
OE 1.54 (0.96–1.93)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.25Z-score
OE missense 1.26 (1.13–1.41)
232 obs / 184.1 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.54 (0.96–1.93)
0≤0.351.4
Missense OE?1.26 (1.13–1.41)
0≤0.61.4
Synonymous OE?1.07
0≤1.21.6
LoF obs/exp: 13 / 8.5Missense obs/exp: 232 / 184.1Syn Z: -0.47

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TAAR5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients