TAAR2

Chr 6

trace amine associated receptor 2

Also known as: GPR58, taR-2

NCBI Gene: 9287ENSG00000146378UniProt: Q9P1P5

Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
5
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.81
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.81LOEUF
pLI 0.000
Z-score -0.73
OE 1.23 (0.81–1.81)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.24Z-score
OE missense 1.05 (0.93–1.18)
193 obs / 184.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.23 (0.81–1.81)
0≤0.351.4
Missense OE?1.05 (0.93–1.18)
0≤0.61.4
Synonymous OE?1.09
0≤1.21.6
LoF obs/exp: 14 / 11.4Missense obs/exp: 193 / 184.0Syn Z: -0.57

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TAAR2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients