TAAR1

Chr 6

trace amine associated receptor 1

Also known as: TA1, TAR1, TRAR1

The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

ResearchGenerating clinical summary…
0
Active trials
74
Pubs (1 yr)
P/LP submissions
P/LP missense
1.43
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.43LOEUF
pLI 0.000
Z-score 0.71
OE 0.73 (0.401.43)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.69Z-score
OE missense 1.14 (1.021.28)
204 obs / 178.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.73 (0.401.43)
00.351.4
Missense OE?1.14 (1.021.28)
00.61.4
Synonymous OE?1.10
01.21.6
LoF obs/exp: 6 / 8.2Missense obs/exp: 204 / 178.2Syn Z: -0.64

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TAAR1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →