SYN2
Chr 3ADsynapsin II
Also known as: SYNII
Synapsin II is a neuronal phosphoprotein that coats synaptic vesicles and regulates neurotransmitter release at presynaptic nerve terminals. Mutations in SYN2 are associated with susceptibility to schizophrenia and have been linked to autism, epilepsy, and bipolar disorder. The gene follows an autosomal dominant inheritance pattern.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
173 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 27 | 0 | 27 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 3 | 114 | 0 | 0 | 117 |
Likely Benign | 0 | 2 | 2 | 3 | 7 |
Benign | 0 | 4 | 1 | 3 | 8 |
| Total | 3 | 120 | 31 | 6 | 160 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
SYN2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools