SULT4A1
Chr 22sulfotransferase family 4A member 1
Also known as: BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1
The protein is a brain-specific sulfotransferase involved in the metabolism of neurotransmitters and drugs in the central nervous system. SULT4A1 is highly constrained against loss-of-function variants, but definitive disease associations with mutations in this gene have not been established in pediatric patients. The gene shows polymorphisms that may be associated with susceptibility to schizophrenia, but causal relationships remain unclear.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
SULT4A1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools