SULT1A2

Chr 16

sulfotransferase family 1A member 2

Also known as: HAST4, P-PST, P-PST 2, ST1A2, STP2, TSPST2

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
7
Pubs (1 yr)
P/LP submissions
P/LP missense
1.58
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.58LOEUF
pLI 0.000
Z-score -0.23
OE 1.06 (0.731.58)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.85Z-score
OE missense 1.18 (1.051.32)
211 obs / 179.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.06 (0.731.58)
00.351.4
Missense OE?1.18 (1.051.32)
00.61.4
Synonymous OE?1.06
01.21.6
LoF obs/exp: 17 / 16.0Missense obs/exp: 211 / 179.2Syn Z: -0.39

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

SULT1A2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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