SULT1A1

Chr 16

sulfotransferase family 1A member 1

Also known as: HAST1/HAST2, P-PST, P-PST 1, PST, ST1A1, ST1A3, STP, STP1

NCBI Gene: 6817ENSG00000196502UniProt: P50225OMIM: 171150

The sulfotransferase SULT1A1 catalyzes sulfate conjugation of hormones, neurotransmitters, and xenobiotics to increase their water solubility and renal excretion, and also metabolizes thyroid hormones and dopamine. This gene shows very low constraint against loss-of-function variants, and no definitive human genetic disease has been established from SULT1A1 mutations. The enzyme plays a role in drug metabolism including acetaminophen and may influence gut-brain metabolic interactions.

OMIMResearchSummary from RefSeq, UniProt
LOEUF 1.54
Clinical Summary— SULT1A1
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint
1.54LOEUF
pLI 0.000
Z-score -0.07
OE 1.02 (0.69–1.54)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
-1.19Z-score
OE missense 1.25 (1.12–1.40)
219 obs / 174.7 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios
LoF OE1.02 (0.69–1.54)
0≤0.351.4
Missense OE1.25 (1.12–1.40)
0≤0.61.4
Synonymous OE1.52
0≤1.21.6
LoF obs/exp: 16 / 15.7Missense obs/exp: 219 / 174.7Syn Z: -3.39

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SULT1A1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Nobiletin alleviates alcoholic fatty liver disease by regulating lipid metabolism and oxidative stress via Ephx1 and Sult1a1.
Zhu H et al.·Phytomedicine
2026
The molecular key in exercise-induced lung cancer prevention: insights from Mendelian randomization and SULT1A1-mediated mechanisms.
Zhu S et al.·Eur J Med Res
2026Functional
Altered expressions of CGRP, SULT1A1, HMGB1, and HIF-1α in the trigeminal ganglion in medication overuse headache in female rats.
Topa EGA et al.·J Headache Pain
2025Open Access
Allosteric Mechanisms Triggering Substrate and Cofactor Binding in the SULT1A1 Dimer as Revealed by Molecular Dynamics Simulations.
Toth D et al.·J Chem Inf Model
2025Open AccessFunctional
SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells.
Kong K et al.·J Med Chem
2025
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients