STK32A

Chr 5

serine/threonine kinase 32A

Also known as: YANK1

NCBI Gene: 202374ENSG00000169302UniProt: Q8WU08

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
6
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.98
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.98LOEUF
pLI 0.000
Z-score 1.64
OE 0.63 (0.41–0.98)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.58Z-score
OE missense 0.89 (0.79–1.00)
188 obs / 211.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.63 (0.41–0.98)
0≤0.351.4
Missense OE?0.89 (0.79–1.00)
0≤0.61.4
Synonymous OE?1.09
0≤1.21.6
LoF obs/exp: 14 / 22.3Missense obs/exp: 188 / 211.7Syn Z: -0.59

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

STK32A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients