STARD7

Chr 2AD

StAR related lipid transfer domain containing 7

STARD7 encodes a protein with molecular carrier activity that is predicted to be involved in ubiquinone biosynthesis and located in mitochondria. Mutations cause familial adult myoclonic epilepsy 2, an autosomal dominant disorder with adult onset as indicated by the phenotype name. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.485).

OMIMResearchSummary from RefSeq, OMIM, UniProt
ADLOEUF 0.481 OMIM phenotype
Clinical SummarySTARD7
Population Constraint (gnomAD)
Constrained for loss-of-function variants (OE-LoF 0.21) despite low pLI — interpret in context.
Some data sources returned errors (1)

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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Moderate LoF intolerance
LoF Constraint
0.48LOEUF
pLI 0.472
Z-score 3.17
OE 0.21 (0.100.48)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint
0.96Z-score
OE missense 0.82 (0.720.93)
177 obs / 216.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.21 (0.100.48)
00.351.4
Missense OE0.82 (0.720.93)
00.61.4
Synonymous OE1.14
01.21.6
LoF obs/exp: 4 / 18.9Missense obs/exp: 177 / 216.7Syn Z: -0.94

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

STARD7 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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