ST14

Chr 11AR

ST14 transmembrane serine protease matriptase

Also known as: ARCI11, CAP3, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15

The protein is an epithelial-derived membrane serine protease that exhibits trypsin-like activity and is involved in terminal differentiation of keratinocytes through prostasin activation and filaggrin processing. Mutations cause congenital ichthyosis, autosomal recessive 11, which presents from birth with abnormal skin keratinization. The gene shows high constraint against loss-of-function variants (LOEUF 0.375) and follows autosomal recessive inheritance.

Summary from RefSeq, OMIM, UniProt
Research Assistant →

Primary Disease Associations & Inheritance

Ichthyosis, congenital, autosomal recessive 11MIM #602400
AR
0
Active trials
59
Pubs (1 yr)
95
P/LP submissions
3%
P/LP missense
0.38
LOEUF
Mechanism
Clinical SummaryST14
Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.56) — some intolerance to loss-of-function variants.
📋
ClinVar Variants
94 unique Pathogenic / Likely Pathogenic· 122 VUS of 386 total submissions

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Moderate LoF intolerance
LoF Constraint
0.38LOEUF
pLI 0.560
Z-score 4.71
OE 0.21 (0.130.38)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint
1.25Z-score
OE missense 0.85 (0.790.92)
457 obs / 538.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.21 (0.130.38)
00.351.4
Missense OE0.85 (0.790.92)
00.61.4
Synonymous OE0.97
01.21.6
LoF obs/exp: 9 / 41.9Missense obs/exp: 457 / 538.8Syn Z: 0.38

ClinVar Variant Classifications

386 submitted variants in ClinVar

Classification Summary

Pathogenic82
Likely Pathogenic12
VUS122
Likely Benign74
Benign65
Conflicting3
82
Pathogenic
12
Likely Pathogenic
122
VUS
74
Likely Benign
65
Benign
3
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
4
2
76
0
82
Likely Pathogenic
5
1
6
0
12
VUS
0
119
3
0
122
Likely Benign
0
16
16
42
74
Benign
0
12
36
17
65
Conflicting
3
Total915013759358

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

ST14 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
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Key Publications
Landmark & review papers · by relevance
PubMed
Top 5 results · since 2015Search PubMed ↗