SPMIP5

Chr 10

sperm microtubule inner protein 5

Also known as: C10orf82

NCBI Gene: 143379ENSG00000165863UniProt: Q8WW14

Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm and nucleus. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.20
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.20LOEUF
pLI 0.011
Z-score 1.22
OE 0.52 (0.26–1.20)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.46Z-score
OE missense 0.86 (0.71–1.04)
75 obs / 87.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.52 (0.26–1.20)
0≤0.351.4
Missense OE?0.86 (0.71–1.04)
0≤0.61.4
Synonymous OE?1.12
0≤1.21.6
LoF obs/exp: 4 / 7.6Missense obs/exp: 75 / 87.1Syn Z: -0.58

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SPMIP5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients