SPMIP11

Chr 12

sperm microtubule inner protein 11

Also known as: LINC00935, TEX49

NCBI Gene: 255411ENSG00000257987UniProt: A0A1B0GTD5

Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and sperm flagellum. Predicted to be active in axonemal A tubule inner sheath. [provided by Alliance of Genome Resources, Apr 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.49
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.49LOEUF
pLI 0.005
Z-score 0.76
OE 0.67 (0.33–1.49)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.67Z-score
OE missense 0.78 (0.63–0.97)
56 obs / 72.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.67 (0.33–1.49)
0≤0.351.4
Missense OE?0.78 (0.63–0.97)
0≤0.61.4
Synonymous OE?0.71
0≤1.21.6
LoF obs/exp: 4 / 6.0Missense obs/exp: 56 / 72.0Syn Z: 1.13

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SPMIP11 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients