SPMIP10

Chr 5

sperm microtubule inner protein 10

Also known as: C5orf48, TEX43, Tseg7

NCBI Gene: 389320ENSG00000196900UniProt: Q6ZNM6

Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Predicted to be active in axonemal B tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.70
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.70LOEUF
pLI 0.001
Z-score 0.28
OE 0.87 (0.45–1.70)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.50Z-score
OE missense 0.83 (0.68–1.03)
60 obs / 72.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.87 (0.45–1.70)
0≤0.351.4
Missense OE?0.83 (0.68–1.03)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 5 / 5.7Missense obs/exp: 60 / 72.0Syn Z: 0.11

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SPMIP10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients