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SPG10
ADspastic paraplegia 10 (autosomal dominant)
The SPG10 protein (also known as KIF5A) is a kinesin heavy chain motor protein that transports cellular cargo along microtubules in neurons. Mutations cause autosomal dominant spastic paraplegia 10, characterized by progressive lower limb spasticity and weakness. This condition typically presents in adulthood and primarily affects the corticospinal tracts.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/SPG10?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
SPG10 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools