SPDYE21

Chr 7

speedy/RINGO cell cycle regulator family member E21

Also known as: SPDYE21P

NCBI Gene: 442572ENSG00000230358UniProt: A0A494C086

Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]

7
ClinVar variants
6
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— SPDYE21
📋
ClinVar Variants
6 Pathogenic / Likely Pathogenic· 1 VUS of 7 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

7 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic6
VUS1
6
Pathogenic
1
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————6
Likely Pathogenic
————0
VUS
————1
Likely Benign
————0
Benign
————0
Total—7

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

SPDYE21 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for SPDYE21

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools