SPCH1

Chr 7AD

speech and language disorder 1

The SPCH1 protein function is not well characterized based on the provided information. Mutations cause speech-language disorder-1, which is inherited in an autosomal dominant pattern. This represents a primary disorder affecting speech and language development in children.

Summary from OMIM
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Primary Disease Associations & Inheritance

Speech-language disorder-1MIM #602081
AD
0
Active trials
2
Pubs (1 yr)
0
P/LP submissions
P/LP missense
LOEUF
LOF
Mechanism· G2P
📖
GeneReview available — SPCH1
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/SPCH1?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

SPCH1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Key Publications
Landmark & review papers · by relevance
PubMed
Constructional apraxia.
Gainotti G et al.·Handb Clin Neurol
2018Review
Gestural apraxia.
Etcharry-Bouyx F et al.·Rev Neurol (Paris)
2017Review
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC