SNHG5

Chr 6

small nucleolar RNA host gene 5

ENSG00000203875
0
ClinVar variants
0
Pathogenic / LP
—
pLI score
1
Active trials
Clinical Summary— SNHG5
💊
Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available
Some data sources returned errors (2)

ncbi: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SNHG5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
SNHG5 Exacerbates Sepsis-Induced Inflammatory Injury in Coronary Artery Endothelial Cells by Regulating METAP2-Mediated IL-8 Secretion.
Deng T et al.·Mediators Inflamm
2026🔓 Open Access
Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells.
Zhang J et al.·Cell Biol Toxicol
2026
Loss of Snhg5 disrupts cell-cycle regulation without altering cystogenesis in a mouse model of polycystic kidney disease.
D'Amico S et al.·Sci Rep
2026🔓 Open AccessFunctional
SNHG5 enhances colorectal cancer metastasis through RNA-protein interaction with GNB2 and activation of canonical Wnt signaling.
Chen X et al.·Noncoding RNA Res
2026🔓 Open Access
Diagnostic Potential of Circulating lncRNA SNHG5 in Osteoporotic Fractures and Its Mechanistic Role in Accelerating Fracture Healing.
Shao C et al.·J Invest Surg
2025
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Periodontitis, Adult

Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs

NOT YET RECRUITING
NCT06351722Necmettin Erbakan UniversityStarted 2024-05-15
Before non-surgical periodontal treatmentnon-surgical periodontal treatment3rd month after non-surgical periodontal treatment

External Resources

Links to major genomics databases and tools